FRONTLINE Spray is the original form of the popular flea treatment. FRONTLINE is usually used as FRONTLINE Spot On, but there are occasions when applying as a spray is more suitable. This can be more difficult to apply, but in some situations is more effective, and there is a longer activation of the treatment. FRONTLINE Spray is licensed for use in both cats and dogs — it should not be used on rabbits.

Please note: this product was previously POM-V now has been relicensed as NFA-VPS.

100 ml Datasheet

100ml (delivering 0.5ml per spray)

Frontline Spray 0.25% w/v Cutaneous Spray Solution

Qualitative and quantitative composition

Fipronil 0.25% w/v

Hydro-alcoholic vehicle q.s. 100.00% w/v

For the full list of excipients, see below.

Pharmaceutical form

Clear, colourless to yellow cutaneous spray solution.

Clinical particulars

Target species

Dogs, cats.

Indications for use

The treatment and prevention of flea (Ctenocephalides species) and tick (Ixodes species) infestations in cats and dogs. The product can be used as part of a treatment strategy for Flea Allergy Dermatitis in cats and dogs where this has been previously diagnosed by a veterinary surgeon. The product controls infestations with Trichodectes canis biting lice on dogs, and Felicola subrostratus biting lice on cats.

Contra-indications

Do not use on sick (systemic diseases, fever…) or convalescent animals. Do not use in rabbits, as adverse reactions and even death could occur.

Special warnings for each target species

Do not exceed the recommended dosage. Avoid contact with the animal’s eyes. Do not spray directly onto areas of broken skin. Allow treated animals to dry in a well ventilated room. Do not confine animals in an enclosed space or pet carrier until the coat is totally dry. In the absence of specific tolerance and efficacy data, the product is not recommended for the treatment of species other than cats and dogs.

When treating infestations of parasites, all in-contact animals should be treated with an appropriate product at the same time.

Special precautions for use in animals

Animals should be weighed accurately prior to treatment.

It is important to make sure that animals do not lick each other following treatment.

There may be an attachment of single ticks. For this reason a transmission of infectious diseases cannot be completely excluded if conditions are unfavourable. Keep treated animals away from fires or other sources of heat, and surfaces likely to be affected by the alcohol spray, for at least 30 minutes following spraying and until the fur is totally dry.

Do not spray on a naked flame or any incandescent material. For external use only.

Special precautions to be taken by the person administering the product to animals

This product can cause mucous membranes and eye irritation. Therefore, contact between the product and the mouth and eyes should be avoided. Following accidental ocular exposure the eye(s) should be rinsed carefully with clean water.

People with a known hypersensitivity to fipronil or any of the other ingredients should avoid contact with the product. Avoid contents coming into contact with the fingers. If this occurs, wash hands with soap and water.

Treated animals should not be handled until the fur is dry, and children should not be allowed to play with treated animals until the fur is dry. It is therefore recommended that animals are not treated during the day, but should be treated during the early evening, and that recently treated animals are not allowed to sleep with owners, especially children.

Spray animals in the open air or a well ventilated room. Do not breathe spray. Do not smoke, drink or eat during application. Wear PVC or nitrile gloves during treatment of animals. It is recommended to wear a waterproof apron for the protection of clothing. If clothing becomes heavily wetted with the product, it should be removed and washed before re-use.

Dispose of gloves after use and then wash hands with soap and water.

Wash splashes from skin with soap and water immediately. If irritation occurs, seek medical advice. People with known sensitivity or asthma may be particularly sensitive to the product. Do not use product if you have previously experienced a reaction to it.

Treatment of multiple animals: Good ventilation is particularly important where several animals are to be treated. Treat multiple animals outside, or reduce the build up of vapour by removing the animals from the treatment room while the alcohol is evaporating and ensure that the treatment room is well ventilated between individual treatments. In addition, ensure that the drying room is well ventilated and avoid housing several recently treated animals within the same air space.

Other precautions

Fipronil may adversely affect aquatic organisms. Dogs should not be allowed to swim in water courses for 2 days after application.

Adverse reactions

If licking occurs, a brief period of hypersalivation may be observed due mainly to the nature of the carrier. Among the extremely rare suspected adverse reactions, transient cutaneous reactions erythema, pruritus or alopecia have been reported after use. Exceptionally, hypersalivation, reversible neurological signs (hyperaesthesia, depression, nervous signs), vomiting or respiratory signs have been observed after use. Do not overdose.

Use during pregnancy, lactation or lay

Laboratory studies did not reveal any teratogenic effect of fipronil in the rat and rabbit. The formulation is very well tolerated by puppies following treatment of the lactating bitch. Data are not available on treatment of pregnant or nursing queens.

Interactions

Do not use simultaneously with other flea products which are applied directly on to the animal.

Amounts to be administered and administration route

Route of administration:

Mechanical pump spray for external use.

Method of administration:

Adjust the pump nozzle to spray setting. Spray the entire body of the animal, and apply from a distance of approximately 10-20 cm.

Apply against the lay of the hair and make sure that the entire coat of the animal is dampened. Ruffle the coat, especially in long haired animals, so that the product penetrates down to the skin. For treatment of the head region, and when treating young or nervous pets, application may be carried out by spraying onto a gloved hand and rubbing the product into the coat. Allow to dry naturally. Do not towel dry.

Posology:

In order to dampen the coat down to the skin, depending on the length of hair, apply 3 to 6 ml per kg bodyweight, (7.5 to 15 mg of active ingredient per kg bodyweight) i.e. 6 to 12 pump applications per kg bodyweight of the 100 ml presentation, or 2 to 4 pump applications of the 250 ml and 500 ml presentations.

The 100ml pack contains approximately 8 treatments for a short haired medium sized cat (4 kg). The 250 ml pack contains approximately 4 treatments for a short haired medium sized dog (20 kg). The 500 ml pack contains approximately 8 treatments for a short haired medium sized dog (20 kg).

Properties:

The formulation contains a coating agent. Therefore, spraying builds up a film and makes the fur glossy. In the absence of safety studies, the minimum treatment interval is 4 weeks. The product is active for up to 3 months against fleas in dogs, and up to 2 months in cats, depending on the environmental challenge. It is effective against tick infestations for up to one month in dogs and cats, depending on the level of environmental challenge.

Puppies and kittens from 2 days of age may be safely treated.

Treatment of bedding, carpets and soft furnishings with a suitable insecticide will aid reduction in environmental challenge and maximize the duration of protection against re-infestation provided by the product. The product is not suitable for direct treatment of the environment. For optimum efficacy, it is not recommended to bathe or shampoo animals in the two days prior to or following treatment with the product. Bathing or shampooing up to four times in two months has been shown to have no significant effect on the residual efficacy of the product. Monthly treatment is recommended when more frequent shampooing is carried out.

Overdose

The risk of experiencing adverse effects may increase when overdosing, so animals should always be treated with the correct dose according to bodyweight.

Pharmacological particulars

ATCvet code: QP53AX15

Pharmacodynamic properties

Fipronil exhibits insecticidal and acaricidal activity against fleas (Ctenocephalides spp.), ticks (Rhipicephalus spp. Ixodes spp.) and lice (Trichodectes spp. and Felicola spp.) in the dog and cat.

Fipronil is a member of the phenylpyrazole family of broad spectrum, non-systemic, insecticides/acaricides, which acts by blocking the GABA receptor to kill the target parasite on contact. The product may aid in the control of a number of ectoparasite species in dogs and cats, including Neotrombicula autumnalis, Sarcoptes spp. and Cheyletiella spp.

Treatment with the product has been shown to result in a significant reduction in the incidence of flea allergy dermatitis in both dogs and cats. When used as part of a strategy for the treatment of flea allergy dermatitis, monthly applications to the allergic patient and to other cats and dogs in the household are recommended.

Pharmaceutical particulars

Excipients

Copolymer of vinylpyrrolidin-2-one and vinyl acetate, Isopropyl alcohol, Water purified.

Major incompatibilities

None known.

Shelf life

Shelf life of the product as packaged for sale: 3 years.

Special precautions for storage

This veterinary medicinal product does not require any special temperature storage conditions. Highly flammable. Protect from direct sunlight.

Immediate packaging

Mechanical pumps containing 100 ml (delivering 0.5 ml per spray), and 250 ml and 500 ml (delivering 1.5 ml per spray).

Disposal

Any unused veterinary medicinal product or waste materials derived from such veterinary medicinal products should be disposed of in accordance with local requirements.

Fipronil may adversely affect aquatic organisms. Do not contaminate ponds, waterways or ditches with the product or empty containers.

Marketing Authorisation Number

Vm 08327/4113

250ml Datasheet

250ml (delivering 1.5ml per spray)

Frontline Spray 0.25% w/v Cutaneous Spray Solution

Qualitative and quantitative composition

Fipronil 0.25% w/v

Hydro-alcoholic vehicle q.s. 100.00% w/v

For the full list of excipients, see below.

Pharmaceutical form

Clear, colourless to yellow cutaneous spray solution.

Clinical particulars

Target species

Dogs, cats.

Indications for use

Contra-indications

Do not use on sick (systemic diseases, fever…) or convalescent animals. Do not use in rabbits, as adverse reactions and even death could occur.

Special warnings for each target species

When treating infestations of parasites, all in-contact animals should be treated with an appropriate product at the same time.

Special precautions for use in animals

Animals should be weighed accurately prior to treatment.

It is important to make sure that animals do not lick each other following treatment.

Do not spray on a naked flame or any incandescent material. For external use only.

Special precautions to be taken by the person administering the product to animals

Dispose of gloves after use and then wash hands with soap and water.

Other precautions

Fipronil may adversely affect aquatic organisms. Dogs should not be allowed to swim in water courses for 2 days after application.

Adverse reactions

Use during pregnancy, lactation or lay

Interactions

Do not use simultaneously with other flea products which are applied directly on to the animal.

Amounts to be administered and administration route

Route of administration:

Mechanical pump spray for external use.

Method of administration:

Adjust the pump nozzle to spray setting. Spray the entire body of the animal, and apply from a distance of approximately 10-20 cm.

Posology:

Properties:

Puppies and kittens from 2 days of age may be safely treated.

Overdose

The risk of experiencing adverse effects may increase when overdosing, so animals should always be treated with the correct dose according to bodyweight.

Pharmacological particulars

ATCvet code: QP53AX15

Pharmacodynamic properties

Fipronil exhibits insecticidal and acaricidal activity against fleas (Ctenocephalides spp.), ticks (Rhipicephalus spp. Ixodes spp.) and lice (Trichodectes spp. and Felicola spp.) in the dog and cat.

Pharmaceutical particulars

Excipients

Copolymer of vinylpyrrolidin-2-one and vinyl acetate, Isopropyl alcohol, Water purified.

Major incompatibilities

None known.

Shelf life

Shelf life of the product as packaged for sale: 3 years.

Special precautions for storage

This veterinary medicinal product does not require any special temperature storage conditions. Highly flammable. Protect from direct sunlight.

Immediate packaging

Mechanical pumps containing 100 ml (delivering 0.5 ml per spray), and 250 ml and 500 ml (delivering 1.5 ml per spray).

Disposal

Any unused veterinary medicinal product or waste materials derived from such veterinary medicinal products should be disposed of in accordance with local requirements.

Fipronil may adversely affect aquatic organisms. Do not contaminate ponds, waterways or ditches with the product or empty containers.

Marketing Authorisation Number

Vm 08327/4113

500 ml Datasheet

500ml (delivering 1.5ml per spray)

Frontline Spray 0.25% w/v Cutaneous Spray Solution

Qualitative and quantitative composition

Fipronil 0.25% w/v

Hydro-alcoholic vehicle q.s. 100.00% w/v

For the full list of excipients, see below.

Pharmaceutical form

Clear, colourless to yellow cutaneous spray solution.

Clinical particulars

Target species

Dogs, cats.

Indications for use

Contra-indications

Do not use on sick (systemic diseases, fever…) or convalescent animals. Do not use in rabbits, as adverse reactions and even death could occur.

Special warnings for each target species

When treating infestations of parasites, all in-contact animals should be treated with an appropriate product at the same time.

Special precautions for use in animals

Animals should be weighed accurately prior to treatment.

It is important to make sure that animals do not lick each other following treatment.

Do not spray on a naked flame or any incandescent material. For external use only.

Special precautions to be taken by the person administering the product to animals

Dispose of gloves after use and then wash hands with soap and water.

Other precautions

Fipronil may adversely affect aquatic organisms. Dogs should not be allowed to swim in water courses for 2 days after application.

Adverse reactions

Use during pregnancy, lactation or lay

Interactions

Do not use simultaneously with other flea products which are applied directly on to the animal.

Amounts to be administered and administration route

Route of administration:

Mechanical pump spray for external use.

Method of administration:

Adjust the pump nozzle to spray setting. Spray the entire body of the animal, and apply from a distance of approximately 10-20 cm.

Posology:

Properties:

Puppies and kittens from 2 days of age may be safely treated.

Overdose

The risk of experiencing adverse effects may increase when overdosing, so animals should always be treated with the correct dose according to bodyweight.

Pharmacological particulars

ATCvet code: QP53AX15

Pharmacodynamic properties

Fipronil exhibits insecticidal and acaricidal activity against fleas (Ctenocephalides spp.), ticks (Rhipicephalus spp. Ixodes spp.) and lice (Trichodectes spp. and Felicola spp.) in the dog and cat.

Pharmaceutical particulars

Excipients

Copolymer of vinylpyrrolidin-2-one and vinyl acetate, Isopropyl alcohol, Water purified.

Major incompatibilities

None known.

Shelf life

Shelf life of the product as packaged for sale: 3 years.

Special precautions for storage

This veterinary medicinal product does not require any special temperature storage conditions. Highly flammable. Protect from direct sunlight.

Immediate packaging

Mechanical pumps containing 100 ml (delivering 0.5 ml per spray), and 250 ml and 500 ml (delivering 1.5 ml per spray).

Disposal

Any unused veterinary medicinal product or waste materials derived from such veterinary medicinal products should be disposed of in accordance with local requirements.

Fipronil may adversely affect aquatic organisms. Do not contaminate ponds, waterways or ditches with the product or empty containers.

Marketing Authorisation Number

Vm 08327/4113

Datasheets:

Frontline Spray 0.25% w/v Cutaneous Spray Solution