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Urilin Syrup

Urilin Syrup

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Urilin contains: Active substance: Phenylpropanolamine 40.29 mg (equivalent to 50.0 mg phenylpropanolamine hydrochloride)

Urilin Syrup is used for the treatment of urinary incontinence associated with acquired urethral sphincter incompetence in the bitch only. The efficacy of phenylpropanolamine has only been demonstrated in ovariohysterectomised bitches. Dosage and administration For oral administration. 0.8 mg/kg body weight phenylpropanolamine (equivalent to 1 mg/kg phenylpropanolamine HCl) three times daily in the feed, corresponding to 0.1 ml Urilin syrup/5 kg body weight three times daily. 1 drop for every 2.34 kg body weight three times daily in feed.

Contraindications, warnings, etc Please see Use during pregnancy and lactation. Do not use Urilin in animals treated with non-selective monoamine oxidase inhibitors. Do not use Urilin in cases of known hypersensitivity to the active substance or to any of the excipients. Special warnings for each target species: It is not appropriate to use the product for the behavioural cause of inappropriate urination. Special precautions for use in animals: Because phenylpropanolamine is a sympathomimetic agent, it may affect the cardiovascular system, especially blood pressure and heart rate, and therefore should be used with caution in animals with cardiovascular diseases. Care should be exercised in treating animals with severe renal or hepatic insufficiency, diabetes mellitus, hyperadrenocorticism, glaucoma or other metabolic disorders. In bitches less than 1 year old the possibility of anatomical disorders contributing to incontinence should be considered prior to treatment. Special precautions to be taken by the person administering the veterinary medicinal product to animals: Phenylpropanolamine hydrochloride is toxic when overdoses are ingested. Adverse effects may include dizziness, headache, nausea, insomnia or restlessness, and increased blood pressure. High overdose may be fatal, especially in children. In the event of accidental skin contact, wash the contaminated area with soap and water. Wash hands after use of the product. In the event of accidental eye contact, rinse the eye with clean water for about 15 minutes and seek medical advice.

To avoid accidental ingestion, Urilin must be used and kept out of the reach and sight of children. Always replace the cap firmly after use to ensure the child resistant closure operates correctly. In the event of accidental ingestion, seek immediate medical attention showing the doctor the package leaflet. Adverse reactions: In some dogs, loose stools, liquid diarrhoea, a decrease in appetite, arrhythmia and collapse have been reported following treatment with phenylpropanolamine. Treatment was continued depending on the severity of the undesirable effect observed. As phenylpropanolamine is a sympathomimetic agent it is possible to produce a wide range of effects, most of which mimic the results of excess stimulation of the sympathetic nervous system (e.g. effects on the heart rate and blood pressure). Dizziness and restlessness have been reported in some dogs following treatment. Hypersensitivity may occur in very rare cases. Use during pregnancy and lactation: Do not use in pregnant or lactating bitches. Interactions: Care should be exercised in administering the product with other sympathomimetic drugs, anticholinergic drugs, tricyclic antidepressants or specific type B monoamine oxidase. Overdose: In healthy dogs, no side effects were observed at up to 5 times the recommended dose. However, an overdose could produce signs of excessive stimulation of the sympathetic nervous system. Treatment should be symptomatic. Alpha-adrenergic blockers may be appropriate in the case of severe overdose. However, no specific recommendation on drugs or dosages can be given. Incompatibilities: None known.

Pharmaceutical precautions: Do not store Urilin above 25°C. Keep the container in the outer carton. Do not use after the expiry date stated on the label after EXP. Shelf life of the veterinary medicinal product as packaged for sale: 3 years. Shelf life after first opening the immediate packaging: 3 months. Disposal: Any unused veterinary medicinal product or waste materials derived from such veterinary medicinal products should be disposed of in accordance with local requirements.